Journal
FRONTIERS IN IMMUNOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00640
Keywords
Th17 Cells; osteoclasts; bone marrow; inflammatory bowel diseases; osteoporosis; osteoimmunology
Categories
Funding
- Fondation pour la Recherche Medicale [DEQ20130326467]
- Agence Nationale de la Recherche (ANR)
- Arthritis Fondation
- Societe Francaise de Rhumatologie
- Societe Francophone du Diabete (SFD)
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Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4(+) T cells are central players in this crosstalk. There is an emerging understanding that CD4(+) T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4(+) T cells in the BM is still a matter of investigation. This article describes the CD4(+) T cell populations of the BM and reviews their role as osteoclastogenic population in inflammatory bowel disease.
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