Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 6, Issue 35, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01796d
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Funding
- AXA Chair
- AXA Research Fund
- Spanish Ministry of Economy and Competitiveness MINECO [CTQ2016-76721-R]
- University of Trieste
- Diputacion Foral de Gipuzkoa program Red [101]
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Carbon nanodots (CNDs) hold great potential in imaging and drug delivery applications. In this study, nitrogen-doped CNDs (NCNDs) were coupled to the anticancer agent paclitaxel (PTX) through a labile ester bond. NCNDs showed excellent cell viability and endowed the NCND-PTX conjugate with good water solubility. The hybrid integrates the optical properties of the nanodots with the anticancer function of the drug into a single unit. Cytotoxicity was evaluated in breast, cervix, lung, and prostate cancer cell lines by the MTT assay while the cellular uptake was monitored using confocal microscopy. NCND-PTX induced apoptosis in cancer cells exhibiting slightly better anticancer activity compared to the drug alone. Moreover, the course of the NCND-PTX interaction with cancer cells was monitored using an xCELLigence system. The NCND-based conjugate represents a promising platform for bioimaging and drug delivery.
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