Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 41, Pages 7141-7148Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01038h
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Funding
- Natural Science Foundation of China [21161003, 21364002]
- Guangxi Natural Science Foundation of China [2013GXNSFGA019001, 2012GXNSFDA053007]
- Program for New Century Excellent Talents in University of the Ministry of Education [NCET-13-0743]
- Program for New Century National Hundred, Thousand and Ten Thousand Talent Project of Guangxi
- State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2012-A12]
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In this paper, we present a new and facile one-step method for the fabrication of a water-soluble graphene-phthalocyanine (GR-Pc) hybrid material by simply sonicating GR with a hydrophilic Pc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc). In the resultant hybrid material, TSCuPc is coated on the skeleton of pristine GR via non-covalently pi-pi interaction, detailedly characterized by UV-vis/Raman spectra, X-ray photoelectron spectroscopy (XPS), etc. The obtained GR-Pc hybrid (GR-TSCuPc) is applied for photothermal therapy (PTT) and photodynamic therapy (PDT). In this PTT/PDT system, both GR and TSCuPc operate as multifunctional agents: GR acts as a photosensitizer carrier and PTT agent, while TSCuPc acts as a hydrophilic PDT agent. Furthermore, the results of cell viability show that the phototherapy effect of GR-TSCuPc is observably higher than that of free TSCuPc, indicating that combined noninvasive PTT/PDT exhibits better anti-cancer efficacy in vitro. Such results highlight that this work provide a facile method to develop efficacious dual-modality carbon nanoplatform for developing cancer therapeutics.
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