Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 44, Pages 7685-7693Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01436g
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Funding
- NIH Director's New Innovator Award [1DP20D006462-01]
- National Institute of Biomedical Imaging and Bioengineering of the NIH [1R21NS085569-01]
- N.J. Commission on Spinal Cord grant [CSCR13ERG005]
- Rutgers IAMDN
- NSF DGE, Integrative Graduate Education and Research Traineeship (IGERT) on the Integrated Science and Engineering of Stem Cells [0801620]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS085569] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006462] Funding Source: NIH RePORTER
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Remotely-triggerable drug delivery systems enable the user to adjust dosing regimens on-demand based on a patient's physiological response and clinical needs. However, currently reported systems are limited by the non-specific leakage of drugs in the absence of triggering and the lack of repeatability over multiple cycles of release. To this end, we have designed a unique hydrogel-nanoparticle hybrid scaffold that provides a chemically-defined, remotely-triggerable and on-demand release of small molecule drugs. Our hybrid platform consists of three distinct components: (1) a photo-triggerable chemical compound, which serves to release a covalently-bound drug upon photo-irradiation, (2) a nanoparticle, which serves to covalently bind the photo-triggerable compound, and (3) a polymeric hydrogel, which serves to hold the drug-conjugated nanoparticle. Upon photo-irradiation, the activation of the photo-triggerable compound is designed to initiate a series of intramolecular chemical rearrangements, which would cleave the covalently-bound drug and release it from the hydrogel. The combination of these distinct components in a single scaffold proved to be an effective drug delivery system, as demonstrated by the delivery of a model drug to a malignant cancer line. Our hybrid scaffold can be easily tuned for practically any biological application of interest, thus offering immense potential for clinical therapies.
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