Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 33, Pages 5409-5418Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00399c
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Funding
- National High Technology Research and Development Program of China (863 Program) [SS2014AA020538]
- Science Foundation for Distinguished Young Scholars of Guangdong Province
- Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Program for New Century Excellent Talents in University
- YangFan Innovative & Entepreneurial Research Team Project
- Research Fund for the Doctoral Program of Higher Education of China
- China Postdoctoral Science Foundation
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Selenium nanoparticles (SeNPs) have been widely used in various biomedical applications, including cancer therapy, diagnosis and drug delivery. Herein, we fabricated a novel type of structure-transformable capsules by decoration of SeNPs with folate-chitosan to form smart-shell nanocapsules (FAC@CurP-SeNPs). The shrink particles could target cancer cells over expressing folate receptor and enter the cells via folate receptor-mediated endocytosis. FAC@CurP-SeNPs were expanded to snowflake particles under acidifying stimulus (pH 5.3), which led to enhanced drug-release over prolonged periods. Treatment with FAC@CurP-SeNPs significantly inhibited the growth of MCF-7 human breast carcinoma cells through induction of apoptosis, which was evidenced by accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation. The contribution of extrinsic and intrinsic apoptotic pathways to the cell apoptosis was confirmed by activation of caspase-9 and caspase-8. Internalized FAC@CurP-SeNPs triggers intracellular ROS overproduction, thus activates p53, MAPKs pathways and inhibits NFkB and to promote cell apoptosis. Our results suggest that FAC@CurP-SeNPs may be a candidate for further evaluation as a agent for human cancers, and the strategy to use transformable nanocapsules could be a highly efficient way to enhance controlled drug release and anticancer efficacy.
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