Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 41, Pages 7176-7185Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00925h
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Funding
- NSF [CBET-1133883, CBET-1347130, DMR 1310149]
- NSF GK-12 program [0947869]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1310149] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1414274] Funding Source: National Science Foundation
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Many magnetic materials lack intrinsic biocompatibility and require surface functionalization for in vivo applications. In this study, we fabricated an intrinsically biocompatible, biodegradable magnetic material through iron substitution into hydroxyapatite (FeHA) via ion-exchange. Controlling the oxidation state of iron in the ion exchange solution resulted in 'tunable' magnetic properties. Superparamagnetic behavior was observed in Fe(2+)HA and Fe(2+3+)HA and paramagnetism in Fe(3+)HA. FeHA powders were characterized using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infra-red (FTIR) and X-ray photoelectron spectroscopy (XPS) with no detection of iron oxide phases. The as-synthesized HA and Fe(2+3+)HA samples were characterized in vitro using MC3T3-E1 cells. Cellular proliferation of Fe(2+3+)HA was found comparable to HA, while our cytotoxicity results from a lactate dehydrogenase assay showed Fe(2+3+)HA to be less toxic than pure HA, a widely used implantable biomaterial. Thus, these results collectively suggest that we have fabricated a magnetic biomaterial with intrinsic biocompatibility.
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