Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 46, Pages 8106-8109Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00967c
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Funding
- National Institutes of Health [R21EB013274, U54CA151838]
- Institute for NanoBioTechnology at Johns Hopkins University
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PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surface charges, correlating with improved transfection efficiency.
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