Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 41, Pages 7132-7140Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01193g
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Funding
- National Basic Research Program of China (973 Program) [2012CB933600, 2010CB933901]
- National Natural Science Foundation of China [51472259, 51172260, 51102258]
- Fund for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructure
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Biodegradable inorganic mesoporous materials hold promise for various biomedical applications such as drug/gene delivery, bioimaging, and photodynamic/photothermal and ultrasound therapy. Herein, multifunctional mesoporous microspheres of europium-doped amorphous calcium phosphate (Eu3+-doped ACP) have been prepared using a natural biomolecule adenosine triphosphate (ATP) by the rapid microwave-assisted solvothermal method. This method has advantages such as surfactant-free, rapid and energy-saving. The ATP molecule plays key roles as a phosphate source and a structure mediator. Furthermore, the Eu3+-doped ACP mesoporous microspheres exhibit advantages such as high specific surface area (from 253 to 315 m(2) g(-1)), high biocompatibility, pH-responsive drug release, and in vitro/in vivo fluorescence imaging properties. The mechanism of pH-responsive drug release can be explained by the degradation of ACP mesoporous microspheres at low pH. The docetaxel-loaded Eu3+-doped ACP mesoporous microspheres showed good anticancer performance in vitro. The as-prepared Eu3+-doped ACP mesoporous microspheres are promising for applications in drug delivery, tissue engineering, bioimaging, etc.
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