4.6 Article

Highly water-soluble perylenediimide-cored poly(amido amine) vector for efficient gene transfection

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 20, Pages 3079-3086

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00195h

Keywords

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Funding

  1. 973 Program [2013CB127603]
  2. National Science Foundation of China [21174012, 51103008, 51221002, 31372255]
  3. Beijing Natural Science Foundation [2142026]
  4. Special Fund for Agro-scientific Research in the Public Interest [201003025]
  5. New Century Excellent Talents Award Program from the Ministry of Education [NCET-10-0215]
  6. Doctoral Program of Higher Education Research Fund [20120010110008]

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A highly water-soluble perylenediimide-core poly(amido amine) (PDI-PAmAm) with peripheral amine groups has been synthesized. The central PDI chromophore allows optical monitoring of relevant cellular experiments by fluorescence microscopy. The PAmAm shell provides the steric bulk that notably suppresses the aggregation of the central PDI chromophore in aqueous solution. The peripheral amines provide water solubility and positive charges, and also serve as active sites for the further growth of PAmAm. PDI-PAmAm can be rapidly internalized into live cells with high efficacy of gene delivery and low cytotoxicity. Both in vitro and in vivo experiments demonstrate the high gene transfection efficacy of PDI-PAmAm.

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