Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 9, Pages 1121-1124Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21617a
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Funding
- National Natural Science Foundation of China [21322505, 21175008, 21073005, 51121091]
- Ministry of Science and Technology of China [2012IM030900]
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A one-step and template-free method to prepare uniform SnO2 nanospheres with a mesoporous structure was developed for the applications in phosphopeptide enrichment. The as-synthesized mesoporous SnO2 nanospheres have a large surface area and highly active surfaces for the effective binding of phosphopeptides. Compared with the non-porous SnO2 and commercial TiO2, mesoporous SnO2 nanospheres represent superior performance in the specific trapping of phosphopeptides from both standard protein and complex nonfat milk digests for mass spectrometry-based phosphoproteomic analysis. The feasible synthetic approach and the excellent enrichment performance make the mesoporous SnO2 nanospheres promising in further phosphoproteomic research.
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