Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 40, Pages 6917-6923Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00570h
Keywords
-
Categories
Funding
- National Basic Research Program of China [2012CB124702, 2012CB619100]
- International Science and Technology Cooperation Program of China [S2013ZR0398]
- International Science and Technology Cooperation Program of Chongqing [CSTC2013gjhz80002]
- China 863 Project [2014AA021602, 2012AA020504]
- Chongqing Basic Scientific Research Grant [cstc2013jcyjC80001]
- Chongqing Agriculture Development Grant [14408, 12402]
- NSERC
- Manitoba Health Research Council
- Dr J. A. Moorhouse Fellowship
- Manitoba Diabetes Foundation
- Manitoba Institute of Child Health
- National Natural Science Foundation of China [21304098]
- Jiangsu Province Science Foundation [BK2011844]
- Six talent peak project fund, Personnel of Jiangsu Province Project [WSW-021]
Ask authors/readers for more resources
In the fabrication of 3-D complex tissues for implantation, layer-by-layer (LBL) electrospun nanofibrous scaffolds have recently received intensive interest. However, poor cell adhesion and cell expansion between the layers in an LBL stack remain important issues. In this study, we report a mussel-inspired, biomimetic approach to functionalize the surface of PCL/gelatin nanofibrous membranes coated with poly (dopamine) (PDA). Our study demonstrates that a PDA coating on electrospun PCL/gelatin nanofibers leads to a significant change in their surface properties and a higher adhesion force. Furthermore, we found that PDA coating promotes the adhesion and growth of adipose stem cells (ADSCs). In 3-D LBL stacked scaffolds, more cells survived in a PAD-coated scaffold than in a non-coated one. The PDA coating was further demonstrated to promote the osteogenic differentiation of ADSCs in LBL paper-stacking membranes. Our study suggests that PDA-coated paper-stacking nanofiber membranes present a facile and economic method for the development of 3D tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available