Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 9, Pages 1182-1189Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21269f
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Funding
- National Natural Science Foundation of China [21176164, 21301125]
- Natural Science Foundation of Jiangsu Province [BK2012625]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [13KJB430022]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Joint Research Projects of SUN-WIN Joint Research Institute for Nanotechnology
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Herein, light-responsive nanocarriers based on hollow mesoporous silica (HMS) nanoparticles modified with spiropyran-containing light-responsive copolymer (PRMS-FA) were fabricated via a simple self-assembly process. HMS modified with long-chain hydrocarbon octadecyltrimethoxysilane was an ideal base material owing to its good biocompatibility and drug capability. The spiropyran-containing amphiphilic copolymer could shift its hydrophilic-hydrophobic balance to become hydrophilic upon UV (lambda = 365 nm) irradiation and then break away from the hydrophobic surface of the HMS core, followed by the uncaging and release of the pre-loaded anticancer drug. Simultaneously, the fluorescence resonance energy transfer (FRET) process based on the structural transformation of PRMS-FA was observed, which could act as a real-time monitor for the light-controlled drug release. Our model experiments in vitro tested and verified that this composite nanocarrier has good biocompatibility, active tumour targeting to the folate receptor over-expressed in tumour cells, is non-toxic to normal cells and that light-controlled drug release with real-time monitoring can be achieved.
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