Journal
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Volume 6, Issue 2, Pages 132-147Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-015-0234-2
Keywords
Osteoarthritis; Drug delivery; Controlled release; Drug targeting
Funding
- NIAMS NIH HHS [R21 AR060408] Funding Source: Medline
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Osteoarthritis (OA) is a disease characterized by degradation of joints with the development of painful osteophytes in the surrounding tissues. Currently, there are a limited number of treatments for this disease, and many of these only provide temporary, palliative relief. In this review, we discuss particle-based drug delivery systems that can provide targeted and sustained delivery of imaging and therapeutic agents to OA-affected sites. We focus on technologies such as polymeric micelles and nano-/microparticles, liposomes, and dendrimers for their potential treatment and/or diagnosis of OA. Several promising studies are highlighted, motivating the continued development of delivery technologies to improve treatments for OA.
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