Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 2, Issue 6, Pages 629-636Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21278e
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Funding
- National Science Council (NSC) [101-3113-E-011-002, 101-2923-E-011-001-MY3]
- Top University Projects of Ministry of Education (MOE) [102H451401]
- National Taiwan University of Science and Technology (NTUST) [TMU-NTUST-100-07]
- Taipei Medical University (TMU) [TMU-NTUST-100-07]
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A highly sensitive self-focusing surface-enhanced Raman scattering (SERS) methodology has been developed using Au@SiO2 core-shell nanorods for carcinoembryonic antigen (CEA) detection. The SERS enhancement factor was evaluated for anisotropic Au@SiO2 nanorods with silica shells of various thicknesses, upon which Rhodamine 6G (R6G) dye was applied as a reporter molecule for the quantitative determination of CEA. The highest R6G signal was attained with a silica layer of 1-2 nm thickness. The self-focusing character originates from the antibody-antigen interaction, which facilitates the SERS probes assembly and significantly increases the detection sensitivity of the CEA. Our results show that the SERS technique is able to detect CEA within a wide concentration range. With an extremely low limit of detection (LOD) of 0.86 fg mL(-1), the Au@SiO2 nanoprobes potentially enable the early diagnosis of cancer. Our work offers a low-cost route to the fabrication of sensing devices able to be used for monitoring cancer progression in natural matrices, such as blood.
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