Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 42, Pages 5762-5767Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20986e
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Funding
- National Basic Research Program of China [2010CB732403]
- National Natural Science Foundation of China [21125524, 20975023]
- Program for New Century Excellent Talents in the University of China [09-0014]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
- National Science Foundation of Fujian Province [2010J06003]
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Graphene oxide (GO) has many exciting advantages such as easy preparation, low toxicity, good solubility and stability in aqueous solution. However, GO itself has a low near-infrared (NIR) absorption, and thus is not suitable for photothermal therapy and photoacoustic imaging. To overcome this limitation, a novel dye-enhanced GO is prepared utilizing the pi-pi stacking interactions between GO and indocyanine green (ICG). The ICG-GO complex has a high optical absorbance in the NIR region and exhibits excellent photothermal properties under NIR irradiation. In order to improve the cancer-targeting activity, GO was modified with folic acid (FA). In vitro experiments showed that the ICG-GO-FA nanocomposite could be used for targeted photothermal cancer cell destruction. Moreover, the application of the ICG-GO-FA nanocomposite for photoacoustic imaging was also demonstrated.
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