Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 7, Pages 997-1001Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2tb00317a
Keywords
-
Categories
Funding
- CAREER award from National Science Foundations
- National Natural Science Foundation of China [30900348]
- Natural Science Foundation of Chongqing [CSTC2013JJB0117]
- Third Military Medical University [2010XZH08]
- Air Force Office of Scientific Research
- National Science Foundation EAGER Program
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1342940, 1239759] Funding Source: National Science Foundation
Ask authors/readers for more resources
Increasing acidity is a promising method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. However, conventional ways of pH control are not reversible, which can cause continuous changes in cellular and biological behaviours and are harmful to the host. Utilizing a photoacid that can reversibly alter pH over two units, we demonstrated a strong bacterial inhibition assisted by visible light. The pH value of the solution reverts back to the original level immediately after the irradiation is stopped. If a photoacid is combined with colistin, the minimum inhibitory concentration (MIC) of colistin on multidrug-resistant (MDR) Pseudomonas aeruginosa can be improved similar to 32 times (from 8 to 0.25 mu g mL(-1)), which significantly decreases the toxicity of colistin in clinics. Evidenced by the extremely low toxicity of the photoacid, this strategy is promising in MDR bacteria killing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available