4.6 Article

Strategy to introduce an hydroxyapatite-keratin nanocomposite into a fibrous membrane for bone tissue engineering

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 4, Pages 432-437

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2tb00460g

Keywords

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Funding

  1. Hong Kong Innovation and Technology Commission
  2. Hong Kong Research Institute of Textile and Apparel [ITP/001/07TP, ITP/031/08TP]
  3. Hong Kong Research Grant Council
  4. Hong Kong Polytechnic University [PolyU5242/09E, G-YX1M, J-BB6Q, GU942]
  5. Guangdong Provincial Department of Science and Technology through the Guangdong-Hong Kong International Textile Bioengineering Joint Research Center [2011B050300023]
  6. Biomedical Textile Industry Roadmap [2012B050800002]
  7. Hong Kong Jockey Club Sports Medicine and Health Science Center

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An hydroxyapatite (HA)-keratin nanocomposite was introduced into an electrospun poly(L-lactic acid) (PLLA) fibrous membrane with good electrospinnability. Biological in vitro cell culture demonstrated that the incorporation of HA-keratin into PLLA fibers led to significant bone formation compared to that of the pure electrospun PLLA membrane.

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