Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 18, Pages 2367-2374Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20137f
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Funding
- Fundacao para a Ciencia e Tecnologia - FCT [SFRH/BD/61126/2009, SFRH/BD/73119/2010, SFRH/BD/69529/2010]
- Fundo Social Europeu - FSE
- Programa Diferencial de Potencial Humano - POPH
- TUBITAK [111M232]
- COST Action [TD0906]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/61126/2009, SFRH/BD/69529/2010, SFRH/BD/73119/2010] Funding Source: FCT
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Medical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan and the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage of the electrostatic self-assembly mechanism of LbL, the charges of both chitosan and a phosphonate-derivatized levan (Ph-levan) are measured and the feasibility of constructing hybrid films is monitored and confirmed using a quartz crystal microbalance with dissipation monitoring (QCM-D). The adhesive properties between two identical bonded films with a total of 100 layers are compared to control films in which Ph-levan is replaced by alginate, revealing that the detachment force of the former is about 3 times higher than the control. Scanning electron microscopy of the films surface shows that the surface of Ph-levan films is smooth and homogeneous. Cell adhesion tests were conducted using a L929 cell line. Early cell adhesion is significantly higher in chitosan/Ph-levan films when compared to chitosan/alginate controls. These findings establish levan derivatives as bioinspired ingredients for conceiving medical adhesive devices that allow achieving enhanced mechanical and biological performance.
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