Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 18, Pages 2350-2357Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb00345k
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- National Science Council of Taiwan [NSC-100-2218-E001-001, NSC 101-2113-M-005-016-MY3]
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A binary molecule can self-assemble to form fluorescent organic nanoparticles (FONs) based on the Aggregation-Induced Emission Enhancement (AIEE) property and subsequently, presents an efficient fluorescence resonance energy transfer (FRET) to generate singlet oxygen under linear and nonlinear light sources. Biologically, this FON-photosensitizer is much more phototoxic to cancer cells than to normal cells without significant dark toxicity. Eventually, a new approach, called FON FRET-PDT or AIEE FRET-PDT, to promote the PDT effect is expected.
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