Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 25, Pages 3144-3151Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20271b
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Funding
- National Natural Science Foundation of China [91027021, 51173124, 51128301]
- National Basic Research Program of China (973 Program) [2010CB934500, 2011CB808400, 2012CB932400, 2013CB933502]
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Heavy-metal-free, organic-small-molecule-based fluorescent nanodots (Sdots, 31-60 nm in diameter) based on 2,7-di(4-(diphenylamino)phenyl-2,1,3-benzothiadiazol-7-yl)-9,9'-spirobifluorene (Spiro-BTA) were prepared through a simple solution process. The Sdots show not only non-blinking and high-brightness fluorescence but also stability in various pH conditions and heavy metal ion solutions. More importantly, Spiro-BTA Sdots demonstrate obviously much higher brightness with very high signal-to-background ratio in Hela cell, compared with common CdSe/ZnS QDs. In addition, they exhibit large Stokes shifts, broad absorption spectra, and low toxicity to living cells which enable their applications as good fluorescence probes for bio-imaging. Further application of Sdots for folate receptor-mediated live-cell endocytosis was demonstrated by non-convalent modification with folic acid linked multidentate ligands.
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