Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 42, Pages 5831-5841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21123a
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Funding
- National Research Foundation of Korea
- Ministry of Education, Science, and Technology (MEST) [NRF-2012R1A2A2A01017435]
- Fishery Commercialization Technology Development Program
- Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea [312019-05-1-sb010]
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Here, we propose a new combinational method supplemented with melt-plotting and in situ plasma treatment to improve the coating ability of chitosan solution. Using the proposed method, the hydrophobic surface of poly(3-caprolactone) (PCL) was altered to a hydrophilic surface to facilitate homogeneous coating of the micro-structured PCL scaffold with chitosan of various molecular weights. The fabricated chitosan-coated PCL scaffolds were assessed in terms of not only physical properties, including tensile strength and water uptake ability, but also biological capabilities by culturing osteoblast-like cells (MG63) in the presence of coatings of chitosan of various molecular weights (1-5, 5-10, and > 10 kDa). The chitosan-based scaffolds showed complete water absorption ability and significantly increased mechanical properties (13-36% increase in Young's modulus) compared to the untreated PCL scaffold. A number of assays (fluorescence analysis, alkaline phosphatase (ALP) activity, and calcium deposition) indicated that the scaffold coated with high-molecular-weight chitosan induced highly active cellular responses that would be of interest for bone-tissue regeneration.
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