Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 13, Pages 1818-1825Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb00448a
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [51103181, 11204033]
- Fundamental Research Funds for the Central Universities
- project of Science and Technology New Star of Zhu Jiang in Guangzhou city
- State Key Laboratory of Bioelectronics of Southeast University
- Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instruments [2011A060901013]
- Research Fund for the Doctoral Program of Higher Education of China [20120092120042]
- Open Fund of The First Affiliated Hospital
- Jinan University Guangzhou
- Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University
Ask authors/readers for more resources
The development of modern biomedical nanotechnology requires conductive polymeric nanofibers with excellent mechanical and biocompatible properties to meet the needs of practical applications in complex biological systems. In the study, we developed a novel facile method to fabricate poly(3,4-ethylenedioxythiophene) (PEDOT) nanofiber mats by electrospinning combined with in situ interfacial polymerization. The PEDOT nanofiber mats displayed superior mechanical properties (tensile strength: 8.7 +/- 0.4 MPa; Young's modulus: 28.4 +/- 3.3 MPa) and flexibility, which can almost be restored to its original shape even after serious twisting and crimping. Especially, from the results of the cellular morphology and proliferation of human cancer stem cells (hCSCs) cultured on the PEDOT nanofiber mats for 3 days, evidence was provided that the PEDOT nanofiber mats have similar biocompatibility to tissue culture plates (TCPs). Combined with an outstanding electrical conductivity of 7.8 +/- 0.4 S cm(-1), these excellent mechanical and biocompatible properties make the PEDOT nanofiber mats promising candidates in biotechnology applications, such as electroactive substrates/scaffolds for tissue engineering, drug delivery, cell culture, and implanted electrodes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available