Journal
CURRENT OSTEOPOROSIS REPORTS
Volume 13, Issue 6, Pages 363-371Publisher
SPRINGER
DOI: 10.1007/s11914-015-0292-x
Keywords
Bone density; Prebiotics; Probiotics; Microbiome; Osteoblast; Osteoclast
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Funding
- NIH [NCCIH RO1AT007695, NIDDK R01DK101050]
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Recent advances in our understanding of how the intestinal microbiome contributes to health and disease have generated great interest in developing strategies for modulating the abundance of microbes and/or their activity to improve overall human health and prevent pathologies such as osteoporosis. Bone is an organ that the gut has long been known to regulate through absorption of calcium, the key bone mineral. However, it is clear that modulation of the gut and its microbiome can affect bone density and strength in a variety of animal models ( zebrafish, rodents, chicken) and humans. This is demonstrated in studies ablating the microbiome through antibiotic treatment or using germ-free mouse conditions as well as in studies modulating the microbiome activity and composition through prebiotic and/or probiotic treatment. This review will discuss recent developments in this new and exciting area.
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