Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 6, Pages 729-739Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2tb00294a
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Funding
- Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea [A085136]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF)
- Korean government (MEST) [2012050077]
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Magnetic nanoparticles offer potential advances in cancer treatment. One example is cancer theranostics, which refers to the combination of a diagnostic tool, i.e., magnetic resonance (MR) imaging, and therapeutic entities such as drugs, oligonucleotides, antibodies, and peptides. They can be conjugated with bioactive molecules and have the ability to form a magnetic field gradient under an external magnetic field. They can offer a variety of active drug delivery and imaging strategies along with modalities such as magnetic hyperthermia. Imaging with magnetic nanoparticles can facilitate more effective cancer therapy through more well informed decision-making. In this article, we review notable progress in magnetic particle design, including surface modifications and multi-functionalization, and we discuss the recent bioapplications of magnetic nanoparticles in simultaneous cancer imaging and therapy.
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