Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 1, Issue 38, Pages 5036-5044Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20855a
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Funding
- NSFC [21144002]
- NSFY of China [21002049]
- NSFJS [BK2011781]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Major Program for the Natural Science Fundamental Research of the Higher Education Institutions of Jiangsu Province [10KJB150005, 12KJA150006]
- Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
- Base of production, education & research of prospective joint research project of Jiangsu Province [BY2011109]
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Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.
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