Hologenome theory and the honey bee pathosphere

Recent research has provided improved genome-level views of diversity across global honey bee populations, the gut microbiota residing within them, and the expanding pathosphere challenging honey bees. Different combinations of bee/microbiota/pathosphere genome complexes may explain regional variation in apiculture productivity and mortality. To understand this, we must consider management and research approaches in light of a hologenome paradigm: that honey bee fitness is determined by the composite bee and microbiota genomes. Only by considering the hologenome can we truly interpret and address impacts from the pathosphere, pesticides, toxins, nutrition, climate and other stressors affecting bee health.