Journal
BIOENGINEERED
Volume 6, Issue 6, Pages 357-360Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2015.1119341
Keywords
Ganoderm lucidum; ganoderic acid production; genetic engineering; genetic transformation; medicinal mushroom
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Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient approach to improve ganoderic acid biosynthesis. However, reliable genetic transformation methods and appropriate genetic manipulation strategies remain underdeveloped and thus should be enhanced. We previously established a homologous genetic transformation method forG. lucidum; we also applied the established method to perform the deregulated overexpression of a homologous 3-hydroxy-3-methyl-glutaryl coenzyme A reductase gene in G. lucidum. Engineered strains accumulated more ganoderic acids than wild-type strains. In this report, the genetic transformation systems of G. lucidum are described; current trends are also presented to improve ganoderic acid production through the genetic manipulation of G. lucidum.
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