4.4 Review

Animal Models of GWAS-Identified Type 2 Diabetes Genes

Related references

Note: Only part of the references are listed.
Article Public, Environmental & Occupational Health

Evaluation of Genome-wide Association Study-identified Type 2 Diabetes Loci in African Americans

Jirong Long et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2012)

Article Genetics & Heredity

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

Richa Saxena et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

Article Hematology

Recent Studies of the Human Chromosome 9p21 Locus, Which Is Associated With Atherosclerosis in Human Populations

Lesca M. Holdt et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Review Biochemical Research Methods

TALE nucleases: tailored genome engineering made easy

Claudio Mussolino et al.

CURRENT OPINION IN BIOTECHNOLOGY (2012)

Article Endocrinology & Metabolism

European genetic variants associated with type 2 diabetes in North African Arabs

S. Cauchi et al.

DIABETES & METABOLISM (2012)

Article Endocrinology & Metabolism

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

L. Shu et al.

DIABETOLOGIA (2012)

Article Endocrinology & Metabolism

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

G. da Silva Xavier et al.

DIABETOLOGIA (2012)

Article Biochemistry & Molecular Biology

Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice

Hyekyung Yang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

Article Biotechnology & Applied Microbiology

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon et al.

NATURE BIOTECHNOLOGY (2012)

Editorial Material Endocrinology & Metabolism

Globalization of Diabetes The role of diet, lifestyle, and genes

Frank B. Hu

DIABETES CARE (2011)

Article Endocrinology & Metabolism

Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth

D. Dabelea et al.

DIABETOLOGIA (2011)

Article Biochemistry & Molecular Biology

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

Daniel Savic et al.

GENOME RESEARCH (2011)

Article Biochemistry & Molecular Biology

TCF7L2 splice variants have distinct effects on β-cell turnover and function

Olivier Le Bacquer et al.

HUMAN MOLECULAR GENETICS (2011)

Article Medicine, Research & Experimental

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

Philippe Ravassard et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biotechnology & Applied Microbiology

Genetic engineering of human pluripotent cells using TALE nucleases

Dirk Hockemeyer et al.

NATURE BIOTECHNOLOGY (2011)

Article Endocrinology & Metabolism

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

Gao Sun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

Review Nutrition & Dietetics

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease

Graham C. Burdge et al.

ANNUAL REVIEW OF NUTRITION, VOL 30 (2010)

Article Endocrinology & Metabolism

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

Dennis T. Villareal et al.

DIABETES (2010)

Article Endocrinology & Metabolism

Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes

Vasanti S. Malik et al.

DIABETES CARE (2010)

Editorial Material Endocrinology & Metabolism

Cancer and diabetes: are we ready for prime time?

U. Smith et al.

DIABETOLOGIA (2010)

Article Endocrinology & Metabolism

Genotype and Tissue-Specific Effects on Alternative Splicing of the Transcription Factor 7-Like 2 Gene in Humans

Ashis K. Mondal et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

Article Genetics & Heredity

A map of open chromatin in human pancreatic islets

Kyle J. Gaulton et al.

NATURE GENETICS (2010)

Article Genetics & Heredity

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F. Voight et al.

NATURE GENETICS (2010)

Review Genetics & Heredity

Gene-environment-wide association studies: emerging approaches

Duncan Thomas

NATURE REVIEWS GENETICS (2010)

Article Endocrinology & Metabolism

Think zinc New roles for zinc in the control of insulin secretion

Guy A. Rutter

ISLETS (2010)

Article Medicine, General & Internal

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

Philippa J. Talmud et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

Article Medicine, General & Internal

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

Philippa J. Talmud et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

Article Nutrition & Dietetics

TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women

Marilyn C. Cornelis et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

Article Medicine, General & Internal

Joint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U. S. Men and Women of European Ancestry

Marilyn C. Cornelis et al.

ANNALS OF INTERNAL MEDICINE (2009)

Article Nutrition & Dietetics

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

Louis A. Lichten et al.

Annual Review of Nutrition (2009)

Article Biochemistry & Molecular Biology

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

Lynley D. Pound et al.

BIOCHEMICAL JOURNAL (2009)

Article Endocrinology & Metabolism

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet beta-Cells

Gabriela da Silva Xavier et al.

DIABETES (2009)

Article Biochemistry & Molecular Biology

Tissue-specific alternative splicing of TCF7L2

Ludmila Prokunina-Olsson et al.

HUMAN MOLECULAR GENETICS (2009)

Review Oncology

The Links between Transcription, β-catenin/JNK Signaling, and Carcinogenesis

Anas Saadeddin et al.

MOLECULAR CANCER RESEARCH (2009)

Article Multidisciplinary Sciences

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

K. Lemaire et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Biochemistry & Molecular Biology

Dietary fats and prevention of type 2 diabetes

Ulf Riserus et al.

PROGRESS IN LIPID RESEARCH (2009)

Article Oncology

Transcription factor 7-like 2 polymrphism and colon cancer

Martha L. Slattery et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

Article Endocrinology & Metabolism

Glucose metabolism in vivo in four commonly used inbred mouse strains

Eric D. Berglund et al.

DIABETES (2008)

Article Biochemistry & Molecular Biology

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

Zhengyu Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Endocrinology & Metabolism

The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus

Tianru Jin et al.

MOLECULAR ENDOCRINOLOGY (2008)

Article Genetics & Heredity

Multiple loci identified in a genome-wide association study of prostate cancer

Gilles Thomas et al.

NATURE GENETICS (2008)

Article Medicine, General & Internal

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

James B. Meigs et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Medicine, General & Internal

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes.

Valeriya Lyssenko et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

A Cre-IoXP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors

Barbara Seidler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Medicine, General & Internal

Active smoking and the risk of type 2 diabetes - A systematic review and meta-analysis

Carole Willi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

Article Endocrinology & Metabolism

Do simple questions about diet and physical activity help to identify those at risk of Type 2 diabetes?

R. K. Simmons et al.

DIABETIC MEDICINE (2007)

Article Medicine, Research & Experimental

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Valeriya Lyssenko et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Medicine, General & Internal

The spread of obesity in a large social network over 32 years

Nicholas A. Christakis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Medicine, General & Internal

Prediction of incident diabetes mellitus in middle-aged adults - The Framingham Offspring Study

Peter W. F. Wilson et al.

ARCHIVES OF INTERNAL MEDICINE (2007)

Article Multidisciplinary Sciences

Wnt signaling regulates pancreatic β cell proliferation

Ingrid C. Rulifson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

A genome-wide association study identifies novel risk loci for type 2 diabetes

Robert Sladek et al.

NATURE (2007)

Article Genetics & Heredity

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

Agnar Helgason et al.

NATURE GENETICS (2007)

Article Developmental Biology

Wnt/β-catenin signaling is required for development of the exocrine pancreas

James M. Wells et al.

BMC DEVELOPMENTAL BIOLOGY (2007)

Article Endocrinology & Metabolism

Adiposity compared with physical inactivity and risk of type 2 diabetes in women

Jamal S. Rana et al.

DIABETES CARE (2007)

Review Endocrinology & Metabolism

Genetics of obesity in humans

I. Sadaf Farooqi et al.

ENDOCRINE REVIEWS (2006)

Review Biochemistry & Molecular Biology

The regulation of INK4/ARF in cancer and aging

William Y. Kim et al.

Article Multidisciplinary Sciences

p16INK4a induces an age-dependent decline in islet regenerative potential

Janakiraman Krishnamurthy et al.

NATURE (2006)

Article Medicine, General & Internal

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

Jose C. Florez et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Developmental Biology

Stabilization of β-catenin impacts pancreas growth

PW Heiser et al.

DEVELOPMENT (2006)

Article Endocrinology & Metabolism

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function

S Papadopoulou et al.

DIABETES (2005)

Article Biochemistry & Molecular Biology

ZnT-8, a pancreatic beta-cell-specific zinc transporter

F Chimienti et al.

BIOMETALS (2005)

Article Multidisciplinary Sciences

Wnt signalling in stem cells and cancer

T Reya et al.

NATURE (2005)

Article Medicine, General & Internal

Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women

FB Hu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Endocrinology & Metabolism

The diabetes risk score -: A practical tool to predict type 2 diabetes risk

J Lindström et al.

DIABETES CARE (2003)

Article Medicine, General & Internal

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

WC Knowler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Endocrinology & Metabolism

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

K Owen et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2001)

Article Medicine, General & Internal

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.

J Tuomilehto et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)