Journal
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
Volume 5, Issue 4, Pages 279-286Publisher
WILEY-BLACKWELL
DOI: 10.1007/s13539-014-0154-x
Keywords
Cachexia; SERCA; Muscle wasting; UCPs; Futile cycles
Funding
- Ministerio de Ciencia y Tecnologia [SAF-26091-2011]
- Programme Alban (European Union Programme of High Level Scholarships for Latin America) [E05D059293BR]
Ask authors/readers for more resources
An alteration of energy balance is the immediate cause of the so-called cachexia. Although alterations of energy intake are often associated with cachexia, it has lately became clear that an increased energy expenditure is the main cause of wasting associated with different types of pathological conditions, such as cancer, infections or chronic heart failure among others. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss; among them, adenosine triphosphate (ATP) consumption by sarcoplasmic reticulum Ca2+ pumps could represent a key mechanism. In other cases, an increase in energy inefficiency will further contribute to energy imbalance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available