Journal
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
Volume 11, Issue 1, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0219720013400076
Keywords
Transcription factors; DNA-binding domains; classification
Categories
Funding
- European Union [202272, 258236]
- German Ministry of Education and Research grant GerontoShield (BMBF) [FKZ0315890B]
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By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.
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