Journal
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
Volume 36, Issue 6, Pages 505-515Publisher
WILEY
DOI: 10.1111/ics.12162
Keywords
infrared spectroscopy; molecular organization; skin barrier lipids; skin permeability; stratum corneum; X-ray diffraction
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Funding
- Firmenich SA
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Synopsis The extracellular matrix of stratum corneum (SC) participates actively in the defensive performance of human skin. Understanding its physicochemical properties is essential for understanding the skin homoeostasis, for the development of efficient therapies for skin disorders and diseases and for ensuring the safety of products designed for topical application. This article summarizes the current knowledge of the composition, self-assembly and molecular organization of the SC lipids, reviews the evidence connecting these parameters and the barrier properties of human skin, and outlines the immediate issues in the field of SC lipid research. ResumeLa matrice extracellulaire du stratum corneum (SC) participe activement a la performance defensive de la peau humaine. Comprendre ses proprietes physico-chimiques est essentielle pour comprendre l'homeostasie de la peau, pour le developpement de therapies efficaces pour les troubles et les maladies de la peau, et pour assurer la securite des produits concus pour une application topique. Cet article resume les connaissances actuelles sur la composition, l'auto-assemblage, et l'organisation moleculaire des lipides SC, examine les preuves reliant ces parametres et les proprietes de barriere de la peau humaine, et decrit les problemes immediats dans le domaine de la recherche sur les lipides SC.
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