Journal
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
Volume 29, Issue 6, Pages 929-939Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2015.09.017
Keywords
Early diagnosis of pancreatic cancer; Risk factors; Endoscopic nasopancreatic drainage (ENPD); Pancreatic cancer in situ (PCIS); Regional network
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Diagnosis of pancreatic cancer (PC) at an early stage with curative surgery should improve long-term patient outcome. At present, improving survival should lie in identifying those cases with high-risk factors or precursor lesions through an effective screening including ultrasonography, some biological markers, or national familial pancreatic cancer registration. Recently, cases with PC < 10 mm with a favorable prognosis have been reported. For the diagnoses of cases with PC < 10 mm, the rate of tumor detection was higher on endoscopic ultrasonography (EUS) than on CT or other modalities, and EUS-guided fine needle aspiration was helpful in confirming the histologic diagnosis. Additionally, for the diagnosis of cases with PC in situ, EUS and magnetic resonance cholangiopancreatography (MRCP) may play important roles in detecting the local irregular stenosis of the pancreatic duct. Cytodiagnosis of pancreatic juice using endoscopic nasopancreatic drainage multiple times may be useful in the final diagnosis. (C) 2015 Elsevier Ltd. All rights reserved.
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