Journal
HEART FAILURE CLINICS
Volume 8, Issue 1, Pages 101-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hfc.2011.08.003
Keywords
Oxidative stress; Progression of heart failure; Stage B heart failure
Categories
Funding
- Abbott Laboratories
- National Institutes of Health [1R01HL103931-01]
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Oxidative stress represents a persistent imbalance between the production and the compensation of reactive oxygen species. Though predominantly found in advanced heart failure, the most frequent at-risk condition has been associated with underlying oxidative stress. It is therefore conceivable that timely detection and early intervention to reduce oxidative stress processes provide an opportunity to prevent disease progression to overt heart failure. This article reviews the current understanding of the current evidence of oxidative stress involvement in the pathophysiology of human heart failure and its potential therapeutic interventions in patients with Stage A and B heart failure.
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