Journal
GENOME BIOLOGY
Volume 15, Issue 2, Pages -Publisher
BMC
DOI: 10.1186/gb-2014-15-2-r30
Keywords
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Funding
- UCL/UCLH Comprehensive Biomedical Research Centre
- Rosetrees Trust
- Wellcome Trust [WT084071, WT093855]
- Royal Society Wolfson Research Merit Award [WM100023]
- IMI-JU OncoTrack [115234]
- EU-FP7 project EPIGENESYS [257082]
- EU-FP7 project IDEAL [259679]
- EU-FP7 project BLUEPRINT [282510]
- PhD CASE Studentship from the UK Medical Research Council [G1000411]
- Cancer Research UK
- Raymond and Beverly Sackler Foundation
- Heller Research Fellowship
- Skeletal Cancer Action Trust (Scat)
- UCLH/UCL Comprehensive Biomedical Research Programme
- UCL Experimental Cancer Centre
- MRC [G100041]
- Cancer Research UK [12183] Funding Source: researchfish
Ask authors/readers for more resources
The integration of genomic and epigenomic data is an increasingly popular approach for studying the complex mechanisms driving cancer development. We have developed a method for evaluating both methylation and copy number from high-density DNA methylation arrays. Comparing copy number data from Infinium HumanMethylation450 BeadChips and SNP arrays, we demonstrate that Infinium arrays detect copy number alterations with the sensitivity of SNP platforms. These results show that high-density methylation arrays provide a robust and economic platform for detecting copy number and methylation changes in a single experiment.
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