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Transcriptional enhancers in development and disease

Journal

GENOME BIOLOGY
Volume 13, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/gb-2012-13-1-238

Keywords

-

Funding

  1. American Heart Association
  2. NIH [T32GM007197]
  3. [HG004428]
  4. [HL088393]
  5. [DK078871]
  6. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL088393] Funding Source: NIH RePORTER
  7. NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004428] Funding Source: NIH RePORTER
  8. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R21DK078871] Funding Source: NIH RePORTER
  9. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007197] Funding Source: NIH RePORTER

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Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.

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