Journal
GENOME BIOLOGY
Volume 13, Issue 4, Pages -Publisher
BMC
DOI: 10.1186/gb-2012-13-4-r28
Keywords
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Funding
- Intramural Research Programs of the NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Library of Medicine (NLM)
- National Institute of Standards and Technology (NIST)
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Background: Gene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by feedback or buffering in expression networks. Results: We profiled expression in engineered flies where gene dose was reduced from two to one. While expression of most one-dose genes was reduced, the gene-specific dose responses were heterogeneous. Expression of two-dose genes that are first-degree neighbors of one-dose genes in novel network models also changed and the directionality of change depended on the response of one-dose genes. Conclusions: Our data indicate that expression perturbation propagates in network space. Autosomal compensation, or the lack thereof, is a gene-specific response, largely mediated by interactions with the rest of the transcriptome.
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