Journal
GENOME BIOLOGY
Volume 12, Issue 6, Pages -Publisher
BMC
DOI: 10.1186/gb-2011-12-6-r60
Keywords
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Funding
- National Institute of Dental and Craniofacial Research [DE017106]
- NIH [AI078942, 1R01HG005969]
- Burroughs Wellcome Fund
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG005969] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI078942] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R21DE017106] Funding Source: NIH RePORTER
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This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.
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