Journal
GENOME BIOLOGY
Volume 12, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/gb-2011-12-1-r1
Keywords
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Funding
- National Human Genome Research Institute [HG03067-05]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U54HG003067] Funding Source: NIH RePORTER
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Genome targeting methods enable cost-effective capture of specific subsets of the genome for sequencing. We present here an automated, highly scalable method for carrying out the Solution Hybrid Selection capture approach that provides a dramatic increase in scale and throughput of sequence-ready libraries produced. Significant process improvements and a series of in-process quality control checkpoints are also added. These process improvements can also be used in a manual version of the protocol.
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