4.4 Editorial Material

What does biologically meaningful mean? A perspective on gene regulatory network validation

Journal

GENOME BIOLOGY
Volume 12, Issue 4, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/gb-2011-12-4-109

Keywords

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Funding

  1. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068429] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM082971] Funding Source: NIH RePORTER
  3. NIDDK NIH HHS [DK068429, R01 DK068429] Funding Source: Medline
  4. NIGMS NIH HHS [GM082971] Funding Source: Medline

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Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

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