Journal
GENOME BIOLOGY
Volume 12, Issue 8, Pages -Publisher
BMC
DOI: 10.1186/gb-2011-12-8-r80
Keywords
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Funding
- Research Council
- Flemish government [G.0318.05, G.0553.06, G.0302.07]
- FWO-research communities [G.0733.09, G.082409]
- IWT-PhD Grants, Silicos
- SBO-BioFrame
- SBO-MoKa [SBO-60848, TBM-IOTA3]
- FOD-Cancer plans
- Belgian Federal Science Policy Office [IUAP P6/25]
- Institute for the Promotion of Innovation
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Detection of chromosomal aberrations from a single cell by array comparative genomic hybridization (single-cell array CGH), instead of from a population of cells, is an emerging technique. However, such detection is challenging because of the genome artifacts and the DNA amplification process inherent to the single cell approach. Current normalization algorithms result in inaccurate aberration detection for single-cell data. We propose a normalization method based on channel, genome composition and recurrent genome artifact corrections. We demonstrate that the proposed channel clone normalization significantly improves the copy number variation detection in both simulated and real single-cell array CGH data.
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