Journal
GENOME BIOLOGY
Volume 11, Issue 3, Pages -Publisher
BMC
DOI: 10.1186/gb-2010-11-3-r30
Keywords
-
Funding
- NHGRI
- CIHR [81340, 84305]
- NSF [BDI-0345474]
- Ministry of Research and Innovation and CIHR [MOP-81340]
Ask authors/readers for more resources
We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally dependent protein complexes. Co-inhibitory compounds were weakly correlated by structure and therapeutic class. We developed an algorithm predicting protein targets of chemical compounds and verified its accuracy with experimental testing. Fitness data provide a novel, systems-level perspective on the cell.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available