Journal
GENOME BIOLOGY
Volume 11, Issue 9, Pages -Publisher
BMC
DOI: 10.1186/gb-2010-11-9-r96
Keywords
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Funding
- NSF [DBI-0820757]
- Roadmap for Medical Research [PN2 EY016586]
- NIH Physical Sciences Oncology Center [U54 CA143907]
- NIH [GM081571, GM092616]
- Department of the Army [W81XWH-04-1-0307]
- NATIONAL CANCER INSTITUTE [U54CA143907] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [PN2EY016586] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM081571, RC2GM092616] Funding Source: NIH RePORTER
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We describe an algorithm, multi-species cMonkey, for the simultaneous biclustering of heterogeneous multiple-species data collections and apply the algorithm to a group of bacteria containing Bacillus subtilis, Bacillus anthracis, and Listeria monocytogenes. The algorithm reveals evolutionary insights into the surprisingly high degree of conservation of regulatory modules across these three species and allows data and insights from well-studied organisms to complement the analysis of related but less well studied organisms.
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