Journal
GENOME BIOLOGY
Volume 10, Issue 11, Pages -Publisher
BMC
DOI: 10.1186/gb-2009-10-11-r134
Keywords
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Funding
- NSF [IIS-0844494]
- NIH [R01-LM006845, R01-HG004885]
- Amazon Web Services Hadoop Testing Program
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004885] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083873] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [R01LM006845] Funding Source: NIH RePORTER
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As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sourceforge.net/crossbow/.
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