Journal
GENOME BIOLOGY
Volume 10, Issue 10, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/gb-2009-10-10-r115
Keywords
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Funding
- National Human Genome Research Institute [HG03067-05]
- Starr Cancer Consortium
- National Institutes of Health [DP2OD002750]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U54HG003067] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD002750] Funding Source: NIH RePORTER
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Targeted RNA-Seq combines next-generation sequencing with capture of sequences from a relevant subset of a transcriptome. When testing by capturing sequences from a tumor cDNA library by hybridization to oligonucleotide probes specific for 467 cancer-related genes, this method showed high selectivity, improved mutation detection enabling discovery of novel chimeric transcripts, and provided RNA expression data. Thus, targeted RNA-Seq produces an enhanced view of the molecular state of a set of high interest genes.
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