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Identifying protein-coding genes in genomic sequences

Journal

GENOME BIOLOGY
Volume 10, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/gb-2009-10-1-201

Keywords

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Funding

  1. European Commission within its FP6 Programme [LHSG-CT-2003-503265]
  2. National Human Genome Research Institute, NIH [U01HG003150, U01HG003147]
  3. Spanish Ministry of Education and Science [BIO2006-03380]
  4. EU AnEUploidy project
  5. NCCR Frontiers in Genetics
  6. Wellcome Trust [RET14/2005]
  7. NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG003147, U54HG004555, U01HG003150] Funding Source: NIH RePORTER

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The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.

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