Journal
GENOME BIOLOGY
Volume 10, Issue 4, Pages -Publisher
BMC
DOI: 10.1186/gb-2009-10-4-r44
Keywords
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Funding
- Intramural Research Program of the NIH
- National Institute of Environmental Health Sciences (NIEHS)
- NIH [P30 AR-46032]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P30AR046032] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES048002] Funding Source: NIH RePORTER
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A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results.
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