Journal
GENOME BIOLOGY
Volume 10, Issue 6, Pages -Publisher
BMC
DOI: 10.1186/gb-2009-10-6-r60
Keywords
-
Funding
- National Human Genome Research Institute
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The most recent release of the finished human genome contains 260 euchromatic gaps (excluding chromosome Y). Recent work has helped explain a large number of these unresolved regions as 'structural' in nature. Another class of gaps is likely to be refractory to clone-based approaches, and cannot be approached in ways previously described. We present an approach for closing these gaps using 454 sequencing. As a proof of principle, we closed all three remaining non-structural gaps in chromosome 15.
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