Journal
GENOME BIOLOGY
Volume 9, Issue 5, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/gb-2008-9-5-r87
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We introduce a novel approach to predict interaction of two proteins solely by analyzing their coding sequences. We found that similarity in codon usage is a strong predictor of protein-protein interactions and, for high specificity values, is as sensitive as the most powerful current prediction methods. Furthermore, combining codon usage with other predictors results in a 75% increase in sensitivity at a precision of 50%, compared to prediction without considering codon usage.
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