Journal
GENOME BIOLOGY
Volume 9, Issue 9, Pages -Publisher
BMC
DOI: 10.1186/gb-2008-9-9-232
Keywords
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Funding
- NIH [CA84208, GM69572]
- Welch Foundation
- American Heart Association
- NATIONAL CANCER INSTITUTE [R01CA084208] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069572] Funding Source: NIH RePORTER
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The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.
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