4.4 Article

NetGrep: fast network schema searches in interactomes

Journal

GENOME BIOLOGY
Volume 9, Issue 9, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/gb-2008-9-9-r138

Keywords

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Funding

  1. NATIONAL CANCER INSTITUTE [P01CA041086] Funding Source: NIH RePORTER
  2. NATIONAL HUMAN GENOME RESEARCH INSTITUTE [T32HG003284] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM071508, R01GM076275] Funding Source: NIH RePORTER
  4. NCI NIH HHS [P01 CA041086, CA041086] Funding Source: Medline
  5. NHGRI NIH HHS [T32 HG003284] Funding Source: Medline
  6. NIGMS NIH HHS [P50 GM071508, GM076275, R01 GM076275] Funding Source: Medline

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NetGrep (http://genomics.princeton.edu/singhlab/netgrep/) is a system for searching protein interaction networks for matches to user-supplied 'network schemas'. Each schema consists of descriptions of proteins (for example, their molecular functions or putative domains) along with the desired topology and types of interactions among them. Schemas can thus describe domain-domain interactions, signaling and regulatory pathways, or more complex network patterns. NetGrep provides an advanced graphical interface for specifying schemas and fast algorithms for extracting their matches.

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